Water → HCID 69332593, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 6-(5-amino-6-bromo-3-phenyl-2-pyrazinyl)-2-isopropyl-3(2H)-pyridazinone (150 mg) and allylamine (0.0881 ml) in 1,3-dimethyl-2-imidazolidinone (0.3 ml) was heated at 120-125° C. for 50 hours. After addition of water (3 ml), an aqueous layer was removed by decantation to give a residue. The residue was dissolved in CHCl3, dried over MgSO4 and concentrated under reduced pressure to give syrup. The syrup was crystallized from a mixture of acetone and hexane to give 6-[6-(allylamino)-5-amino-3-phenyl-2-pyrazinyl]-2-isopropyl-3(2H)-pyridazinone (71 mg).

Provenance & Evidence