Sodium Hydroxide → HCID 69333347, compound

HRID 915087Notes

Reaction equation

HRID 915087 reaction equation
[NH2:1][C:2]1[C:3]([C:25](N)=[O:26])=[N:4][C:5]([C:15]2[CH:20]=[CH:19][C:18](=[O:21])[N:17]([CH:22]([CH3:24])[CH3:23])[N:16]=2)=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[Br:14])[N:7]=1.[OH-:28].[Na+]>CCO>[NH2:1][C:2]1[C:3]([C:25]([OH:28])=[O:26])=[N:4][C:5]([C:15]2[CH:20]=[CH:19][C:18](=[O:21])[N:17]([CH:22]([CH3:24])[CH3:23])[N:16]=2)=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[Br:14])[N:7]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 69331504HCID 69331504, compound

Product 1

HCID 69333347HCID 69333347, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 3-amino-5-(2-bromophenyl)-6-(1-isopropyl-6-oxo-1,6-dihydro-3-pyridazinyl)-2-pyrazinecarboxamide (695 mg) in a mixture of 5N aq. NaOH (4 ml) and EtOH (4 ml) was refluxed for 4 hours. After removal of EtOH by evaporation, the mixture was adjusted to pH 4 with 1N HCl to give a precipitate. The precipitate was collected by filtration and dried under reduced pressure to give 3-amino-5-(2-bromophenyl)-6-(1-isopropyl-6-oxo-1,6-dihydro-3-pyridazinyl)-2-pyrazinecarboxylic acid (664 mg).

Workup

  1. temperaturewas refluxed for 4 hours
  2. customAfter removal of EtOH
  3. customby evaporation
  4. customto give a precipitate
  5. filtrationThe precipitate was collected by filtration
  6. customdried under reduced pressure

Sources & evidence

ORD record
ord-2389a3955cb04119ba694c066230e399
Source dataset
uspto-grants-2007_09
Patent number
US07265120B2

Reaction notes

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