Acetone → HCID 69333244, compound

Participants

Reaction Steps

A mixture of 3-amino-5-(2-bromophenyl)-6-(1-isopropyl-6-oxo-1,6-dihydro-3-pyridazinyl)-2-pyrazinecarboxylic acid (601 mg) in 1,2-dichlorobenzene (3 ml) was refluxed for 2 hours. After cooling, the mixture was purified by column chromatography on silica gel (EtOAc only) to give a solid. The solid was suspended with acetone and collected by filtration to give 6-[5-amino-3-(2-bromophenyl)-2-pyrazinyl]-2-isopropyl-3(2H)-pyridazinone as a solid (554 mg).

Provenance & Evidence