7-chloro-3-(1-tert-butoxycarbonylpiperidin-4-yl)-1H-indole → 7-chloro-3-(piperidin-4-yl)-1H-indole

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Reaction Steps

4-(7-Chloro-1H-indol-3-yl)-piperidine-1-carboxylic acid tert-butyl ester (3.4 g, 10.2 mmol) was set stirring in 1:1 TFA/CH2Cl2. After 45 min the mixture was evaporated and the golden oil brought up in Et2O. A solid formed and was filtered, washed with Et2O and air dried to give 3.5 g (97%) of a white solid. MS (electrospray): exact mass calculated for C12H15ClN2, 234.09; m/z found, 235.1 [M++H].

Provenance & Evidence