Potassium Hydroxide → HCID 55131330, compound

HRID 915166Notes

Reaction equation

HRID 915166 reaction equation
Cl[CH:2](Cl)[CH:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([O:11][C:12]([F:15])([F:14])[F:13])[CH:6]=1)O.[NH2:17][C:18]([NH2:20])=[S:19].[OH-].[K+]>CO>[F:13][C:12]([F:15])([F:14])[O:11][C:7]1[CH:6]=[C:5]([C:3]2[S:19][C:18]([NH2:20])=[N:17][CH:2]=2)[CH:10]=[CH:9][CH:8]=1

Participants

5

Reactant 3

HCID 14797Potassium Hydroxide2×HCID 2723790ThioureaHCID 58958432HCID 58958432, compound

Product 1

HCID 55131330HCID 55131330, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
50 °C

Procedure

19-7 (0.182 g, 0.662 mmol) and thiourea (0.050 g, 0.662 mmol) were dissolved in methanol. Solid potassium hydroxide (0.037 g, 0.662 mmol) was then added and warmed to 50° C. while stirring under N2. Additional solid potassium hydroxide pellets were added until the reaction was complete. The reaction was then directly loaded onto a C18 preparative HPLC column. The titled compound was isolated upon evaporation. H1 NMR (DMSO): 7.75 ppm (s, 1H); 7.51 ppm (m, 3H); 7.26 ppm (d, 2H).

Sources & evidence

ORD record
ord-234be5c7706d44dea093d68234c9be98
Source dataset
uspto-grants-2007_09
Patent number
US07265134B2

Reaction notes

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