HCID 58958458, compound → HCID 58958453, compound

Participants

Reaction Steps

N-cyclopropyl-2-{[(1E)-(dimethylamino)methylidene]amino}-1,3-thiazole-5-carboxamide 23-3 (1.01 g, 4.23 mmol) was heated to 75° C. in 20 mL of concentrated NH4OH in a sealed tube. After 4 hours the hydrolysis was complete and most of the liquid was evaporated off. Additional water was then added and the pH adjusted to 6. The aqueous layer was extracted with ethyl acetate (4×) and all organics were combined, dried, evaporated and flushed with toluene (2×). 1H-NMR (DMSO): 8.06 ppm (s, 1H); 7.55 ppm (s, 1H); 7.42 ppm (s, 2H); 2.68 ppm (m, 1H); 0.64 ppm (m, 2H); 0.48 ppm (m, 2H).

Provenance & Evidence