Ammonia → tert-Butyl 4-amino-4-cyanopiperidine-1-carboxylate
Reaction equation
O=[C:2]1[CH2:7][CH2:6][N:5]([C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9])[CH2:4][CH2:3]1.[NH3:15].[C-]#N.[Na+].[NH4+:19].[Cl-].[CH3:21]O>>[C:11]([O:10][C:8]([N:5]1[CH2:6][CH2:7][C:2]([NH2:19])([C:21]#[N:15])[CH2:3][CH2:4]1)=[O:9])([CH3:14])([CH3:13])[CH3:12]Participants
Procedure
t-Butyl 4-oxo-1-piperidine-carboxylate (10 g, 50 mmol, 1.0 equiv) was dissolved 100 mL of 2 M NH3 in MeOH. NaCN (2.7 g, 55 mmol, 1.1 equiv) and NH4Cl (3 g, 55 mmol, 1.1 equiv) were added and the resulting mixture was refluxed for 2 h at which time an additional 100 mL of 2 M NH3 in MeOH was added followed by another 2 h of reflux. The reaction mixture was cooled and filtered. The MeOH was removed in vacuo and the residue triturated with 100 mL of CH2Cl2 and filtered again. The filtrate was concentrated by about 75% and 200 mL of hexanes was added to give a tan precipitate that was collected by filtration to yield, after drying under vacuum, the desired product as cream-colored solid (10.1 g) which was used without further purification.
Workup
- additionwas added
- temperatureof reflux
- temperatureThe reaction mixture was cooled
- filtrationfiltered
- customThe MeOH was removed in vacuo
- customthe residue triturated with 100 mL of CH2Cl2
- filtrationfiltered again
- concentrationThe filtrate was concentrated by about 75% and 200 mL of hexanes
- additionwas added
- customto give a tan precipitate that
- filtrationwas collected by filtration
- customto yield
- customafter drying under vacuum
- customthe desired product as cream-colored solid (10.1 g) which was used without further purification
Sources & evidence
- ORD record
- ord-10f7f43d0c194f1dbb93e00bf8093693
- Source dataset
- uspto-grants-2007_09
- Patent number
- US07265132B2
Reaction notes
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