HCID 58958500, compound → HCID 77230283, compound

HRID 915265Notes

Reaction equation

HRID 915265 reaction equation
NC1C=CC(C(F)(F)F)=CC=1N[C:13]([C:15]1[N:16]=[C:17]([NH:20][C:21]2[C:26]([Cl:27])=[CH:25][CH:24]=[CH:23][C:22]=2[Cl:28])[S:18][CH:19]=1)=[O:14].NC1C=C(C(F)(F)F)C=CC=1NC(C1N=C(NC2C(Cl)=CC=CC=2Cl)SC=1)=[O:42]>>[Cl:28][C:22]1[CH:23]=[CH:24][CH:25]=[C:26]([Cl:27])[C:21]=1[NH:20][C:17]1[S:18][CH:19]=[C:15]([C:13]([OH:14])=[O:42])[N:16]=1

Participants

3

Reactant 2

HCID 58958500HCID 58958500, compoundHCID 58958508HCID 58958508, compound

Product 1

HCID 77230283HCID 77230283, compound

Procedure

N-[2-Amino-5-(trifluoromethyl)phenyl]{2-[(2,6-dichlorophenyl)amino](1,3-thiazol-4-yl)}carboxamide and N-[2-amino-4-(trifluoromethyl)phenyl]{2-[(2,6-dichlorophenyl)amino](1,3-thiazol-4-yl)}carboxamide. According to the procedure described in step (f) of Example 11, the title compounds were obtained from 2-[(2,6-dichlorophenyl)amino]-1,3-thiazole-4-carboxylic acid (339 mg, 1.18 mmol, prepared analogously to the procedures described in Example 3) and 4-(trifluoromethyl)-1,2-phenylenediamine (207 mg, 1.18 mmol, Lancaster) as a light brown solid. MS (ESI, pos. ion) m/z: 447 (M+1).

Sources & evidence

ORD record
ord-29db05fca68e4401b044d9bfc36006e0
Source dataset
uspto-grants-2007_09
Patent number
US07265138B2

Reaction notes

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