HCID 58958519, compound → HCID 178506087, compound

HRID 915266Notes

Reaction equation

HRID 915266 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[CH:4][C:3]=1[NH:12][C:13]([C:15]1[N:16]=[C:17]([CH2:20][C:21]2[C:26]([Cl:27])=[CH:25][CH:24]=[CH:23][C:22]=2[Cl:28])[O:18][CH:19]=1)=O.NC1C=CC(C(F)(F)F)=CC=1NC(C1N=C(CC2C(Cl)=CC=CC=2Cl)OC=1)=O>>[Cl:28][C:22]1[CH:23]=[CH:24][CH:25]=[C:26]([Cl:27])[C:21]=1[CH2:20][C:17]1[O:18][CH:19]=[C:15]([C:13]2[NH:12][C:3]3[CH:4]=[CH:5][C:6]([C:8]([F:11])([F:10])[F:9])=[CH:7][C:2]=3[N:1]=2)[N:16]=1

Participants

3

Reactant 2

HCID 58958519HCID 58958519, compoundHCID 58958525HCID 58958525, compound

Product 1

HCID 178506087HCID 178506087, compound

Procedure

N-[2-Amino-4-(trifluoromethyl)phenyl]{2-[(2,6-dichlorophenyl)methyl](1,3-oxazol-4-yl)}carboxamide and N-[2-amino-5-(trifluoromethyl)phenyl]{2-[(2,6-dichlorophenyl)methyl](1,3-oxazol-4-yl)}carboxamide. According to the procedure described in step (e) of Example 19, the title product was obtained from 2-[(2,6-dichlorophenyl)methyl]-1,3-oxazole-4-carboxylic acid, Example 19 (d), (0.26 g, 0.97 mmol) and 4-(trifluoromethyl)-1,2-phenylenediamine (0.17 g, 0.97 mmol, Lancaster) as a light-brown solid. MS (ESI, pos. ion) m/z: 430 (M+1).

Sources & evidence

ORD record
ord-0456eaf2a6a3495591488411c1aee175
Source dataset
uspto-grants-2007_09
Patent number
US07265138B2

Reaction notes

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