反应详情

Following general procedure C, (S)-5-aminomethyl-3-[4-(1,1-dioxo-hexahydro-1λ6-thiopyran-4-yl)-3-fluoro-phenyl]-oxazolidin-2-one (2) (492.7 mg, 1.44 mmol) in dichloromethane (13 mL) and butyroyloxymethyl carbonochloridate (7e) gave the titled product in 73% yield (512.1 mg, 1.05 mmol). 1H NMR (400 MHz, CDCl3): δ 7.48 (dd, 1H), 7.23 (t, 1H), 7.16 (dd, 1H), 5.73 (q, 2H), 5.29 (t, 1H), 4.80 (sept, 1H), 4.05 (t, 1H), 3.79 (dd, 1H), 3.67 (ddd, 1H), 3.56 (dt, 1H), 3.13-3.19 (m, 4H), 3.09 (dt, 1H), 2.35-2.47 (m, 2H), 2.31 (t, 2H), 2.14-2.22 (m, 2H), 1.63 (q, 2H), 0.93 (t, 3H). MS-APCI (m/z+): 487 (M+H).