反应详情

Following general procedure C, (S)-5-aminomethyl-3-[4-(1,1-dioxo-hexahydro-1λ6-thiopyran-4-yl)-3-fluoro-phenyl]-oxazolidin-2-one (2) (589.0 mg, 1.72 mmol) in dichloromethane (14 mL) and cyclohexanecarbonoylmethyl carbonochloridate (7j) gave the titled product in 80% yield (722.9 mg, 1.37 mmol). 1H NMR (400 MHz, CDCl3): δ 7.48 (dd, 1H), 7.23 (t, 1H), 7.16 (dd, 1H), 5.72 (q, 2H), 5.29 (t, 1H), 4.76-4.82 (m, 1H), 4.05 (t, 1H), 3.78 (dd, 1H), 3.64-3.70 (m, 1H 3.57 (dt, 1H), 3.13-3.19 (m, 4H), 3.09 (dt, 1H), 2.29-2.46 (m, 4H), 2.16-2.22 (m, 2H), 1.58-1.98 (m, 5H).