Hydrochloric Acid → HCID 86601880, compound

Participants

Reaction Steps

Following General procedure G, except that the entire reaction is performed at RT. 2(S)-tert-Butoxycarbonylamino-3-methyl-butyric acid (acetyl-{3-[4-(1,1-dioxo-hexahydro-1λ6-thiopyran-4-yl)-3-fluoro-phenyl]-2-oxo-oxazolidin-5(R)-ylmethyl}-carbamoyloxy)-methyl ester (12c) (0.40 g, 0.61 mmol), anisole (0.6 mL), THF (12 mL), and 4 M HCl in dioxane (4.6 mL) gave the title compound in 55% yield (0.20 g). 1H NMR (400 MHz, CD3OD): δ 7.51 (dd, 1H), 7.37 (t, 1H), 7.26 (dd, 1H), 6.06 (d, 1H), 6.01 (d, 1H), 4.87 (m, 1H), 4.20 (m, 2H), 4.10 (m, 2H), 3.84 (dd, 1H), 3.37 (m, 2H), 3.24 (tt, 1H), 3.12 (m, 2H), 2.54 (s, 3H), 2.36 (m, 3H), 2.17 (m, 2H), 1.10 (d, 3H), 1.09 (d, 3H). MS-APCI (m/z+): 558.

Provenance & Evidence