Hydrochloric Acid → HCID 11204129, compound

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Reaction Steps

Following general procedure G, 2(R)-tert-Butoxycarbonylamino-3-methyl-butyric acid (acetyl-{3-[4-(1,1-dioxo-hexahydro-1λ6-thiopyran-4-yl)-3-fluoro-phenyl]-2-oxo-oxazolidin-5(R)-ylmethyl}-carbamoyloxy)-methyl ester (12d) (0.89 g, 1.35 mmol), anisole (0.12 mL), THF (25 mL), and 4 M HCl in dioxane (10 mL) gave the title compound in 51% yield (0.41 g). 1H NMR (400 MHz, DMSO): δ 8.52 (br s, 3H), 7.47 (dd, 1H), 7.39 (t, 1H), 7.28 (dd, 1H), 5.98 (d, 1H), 5.93 (d, 1H), 4.80 (m, 1H), 4.14 (m, 2H), 4.03 (d, 1H), 3.90 (dd, 1H), 3.82 (dd, 1H), 3.39 (m, 2H), 3.20 (tt, 1H), 3.10 (m, 2H), 2.47 (s, 3H), 2.17 (m, 3H), 2.04 (m, 2H), 0.98 (d, 3H), 0.96 (d, 3H), MS-APCI (m/z+): 558.

Provenance & Evidence