Hydrochloric Acid → HCID 11227276, compound

Participants

Reaction Steps

Following general procedure G, (R)-(2-tert-Butoxycarbonylamino-acetylamino)-acetic acid (acetyl-{3-[4-(1,1-dioxo-hexahydro-1λ6-thiopyran-4-yl)-3-fluoro-phenyl]-2-oxo-oxazolidin-5-ylmethyl}-carbamoyloxy)-methyl ester (12i) (0.48 g, 0.71 mmol), anisole (0.1 mL), THF (14 mL), and 4 M HCl in dioxane (5 mL) gave the title compound in 66% yield (0.29 g). 1H NMR (400 MHz, CD3OD): δ 7.51 (dd, 1H), 7.36 (t, 1H), 7.26 (dd, 1H), 5.95 (d, 1H), 5.91 (d, 1H), 4.87 (m, 1H), 4.20 (m, 4H), 4.05 (m, 1H), 3.82 (dd, 1H), 3.77 (m, 2H), 3.37 (m, 2H), 3.23 (tt, 1H), 3.12 (m, 2H), 2.53 (s, 3H), 2.35 (m, 2H), 2.18 (m, 2H). MS-APCI (m/z+): 341, 385, 573.

Provenance & Evidence