4-Benzyloxyaniline → 4-(4-Benzyloxyanilino)6-chloropyrido[3,4-d]pyrimidine

HRID 915314Notes

Reaction equation

[CH2:1]([O:8][C:9]1[CH:15]=[CH:14][C:12]([NH2:13])=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl[C:17]1[C:18]2[CH:26]=[C:25]([Cl:27])[N:24]=[CH:23][C:19]=2[N:20]=[CH:21][N:22]=1>>[CH2:1]([O:8][C:9]1[CH:10]=[CH:11][C:12]([NH:13][C:17]2[C:18]3[CH:26]=[C:25]([Cl:27])[N:24]=[CH:23][C:19]=3[N:20]=[CH:21][N:22]=2)=[CH:14][CH:15]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

Reactant 2

HCID 228604-Benzyloxyaniline

HCID 108218764,6-Dichloropyrido[3,4-d]pyrimidine

Product 1

HCID 219521684-(4-Benzyloxyanilino)6-chloropyrido[3,4-d]pyrimidine

Procedure

Prepared according to Procedure A from 4-benzyloxyaniline (1 eq) and 4,6-dichloro-pyrido[3,4-d]pyrimidine (1 eq); δH (CDCl3) 9.11 (1H,s), 8.78 (1H,s), 7.75 (1H,d), 7.56 (2H,dd), 7.40 (5H,m), 7.15 (2H,d), 5.10 (2H,s); m/z (M+1)+ 409.

Workup

customPrepared

Sources & evidence

ORD record: ord-6b94fda01cb04dc0b71b8f8c52c1bb72
Source dataset: uspto-grants-2007_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07265123B2

Reaction notes

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