HCID 11350667, compound → HCID 11444004, compound

HRID 915346Notes

Reaction equation

HRID 915346 reaction equation
[CH2:1]([N:8]1[C:16]2[C:11](=[CH:12][C:13]([N:17]3[C:21]([CH3:22])=[CH:20][CH:19]=[C:18]3[CH3:23])=[CH:14][CH:15]=2)[C:10]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)=[C:9]1[C:30](O)=[O:31])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.C([O:36][C:37](=[O:44])[C@H:38]([CH2:40][CH:41]([CH3:43])[CH3:42])[NH2:39])C>O>[CH2:1]([N:8]1[C:16]2[C:11](=[CH:12][C:13]([N:17]3[C:21]([CH3:22])=[CH:20][CH:19]=[C:18]3[CH3:23])=[CH:14][CH:15]=2)[C:10]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)=[C:9]1[C:30]([NH:39][C@H:38]([C:37]([OH:44])=[O:36])[CH2:40][CH:41]([CH3:43])[CH3:42])=[O:31])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 11350667HCID 11350667, compoundHCID 11658447L-Leucine, ethyl ester, hydrochloride (1:1)

Product 1

HCID 11444004HCID 11444004, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The title compound was prepared from 1-benzyl-5-(2,5-dimethyl-1H-pyrrol-1-yl)-3-phenyl-1H-indole-2-carboxylic acid and L-leucine ethyl ester hydrochloride followed the procedure of Example 2 Step 4 as an off-white solid: 1H NMR (DMSO-d6) δ 0.77 (d, J=6.3 Hz, 3 H), 0.78 (d, J=6.3 Hz, 3 H), 1.25-1.40 (m, 1 H), 1.40-1.50 (m, 1 H), 1.90 (s, 6 H), 4.30-4.40 (m, 1H), 5.56 (d, J=16.0 Hz, 1 H), 5.63 (d, J=16.0 Hz, 1 H), 5.76 (s, 2 H), 7.05-7.65 (m, 13 H), 8.95 (d, J=13.3 Hz, 1 H), 12.35 (br s, 1 H); MS (ESI) m/z 534 (MH−); MS (ESI) m/z 532 ([M-H]−); HRMS calcd for C34H36N3O3: 534.2757; found (ESI+): 534.2745; Anal. calcd for C34H35N3O3.0.65 H2O: C, 74.88; H, 6.71; N, 7.70. Found: C, 74.55; H, 6.31; N, 7.68.

Sources & evidence

ORD record
ord-018bdf3707f24603a7668de2922097af
Source dataset
uspto-grants-2007_09
Patent number
US07265148B2

Reaction notes

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