Methyl iodide → HCID 69282582, compound

HRID 915399Notes

Reaction equation

HRID 915399 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[C:10]([CH2:11][CH3:12])=[C:9]([C:13]2[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=2)[NH:8][N:7]=1)=[O:5])[CH3:2].[CH3:20]I.[OH-].[K+]>>[CH2:1]([O:3][C:4]([C:6]1[N:7]([CH3:20])[N:8]=[C:9]([C:13]2[CH:14]=[CH:15][C:16]([Cl:19])=[CH:17][CH:18]=2)[C:10]=1[CH2:11][CH3:12])=[O:5])[CH3:2].[CH2:1]([O:3][C:4]([C:6]1[C:10]([CH2:11][CH3:12])=[C:9]([C:13]2[CH:14]=[CH:15][C:16]([Cl:19])=[CH:17][CH:18]=2)[N:8]([CH3:20])[N:7]=1)=[O:5])[CH3:2]

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 14797Potassium HydroxideHCID 178470500HCID 178470500, compound

Product 2

HCID 69282582HCID 69282582, compoundHCID 69283052HCID 69283052, compound

Procedure

In analogy to the procedure described for example 2 a], 5-(4-chloro-phenyl)-4-ethyl-1H-pyrazole-3-carboxylic acid ethyl ester was reacted with methyl iodide in the presence of potassium hydroxide to to give 5-(4-chloro-phenyl)-4-ethyl-2-methyl-2H-pyrazole-3-carboxylic acid ethyl ester as yellow crystals and 5-(4-chloro-phenyl)-4-ethyl-1-methyl-1H-pyrazole-3-carboxylic acid ethyl ester as yellow oil.

Sources & evidence

ORD record
ord-4ec3fff76c7f4539b8467e8723ea2677
Source dataset
uspto-grants-2007_09
Patent number
US07265149B2

Reaction notes

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