HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → Ethyl 3-(4-chlorophenyl)-1-methyl-1H-pyrazole-5-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | HCID 178468626 | HCID 178468626 | — |
| Product | Ethyl 3-(4-chlorophenyl)-1-methyl-1H-pyrazole-5-carboxylate | HCID 45790142 | — |
| Product | ethyl 5-(4-chlorophenyl)-1-methyl-1H-pyrazole-3-carboxylate | HCID 45790143 | — |
Reaction Steps
In analogy to the procedure described for example 2 a], 5-(4-chloro-phenyl)-1H-pyrazole-3-carboxylic acid ethyl ester (T. van Herk et al., J. Med. Chem. 2003, 46, 3945-3951) was reacted with methyl iodide in the presence of potassium hydroxide to to give 5-(4-chloro-phenyl)-2-methyl-2H-pyrazole-3-carboxylic acid ethyl ester as colorless crystals and 5-(4-chloro-phenyl)-1-methyl-1H-pyrazole-3-carboxylic acid ethyl ester as colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07265149B2 |
| Source dataset | uspto-grants-2007_09 |
| ORD ID | ord-581b49951e7b4bcc88afe75876bc113f |
| Source note | uspto-grants-2007_09 |