Aluminium lithium hydride → [5-(4-chloro-phenyl)-2-methyl-2H-pyrazol-3-yl]-methanol

HRID 915403Notes

Reaction equation

HRID 915403 reaction equation
C([O:3][C:4]([C:6]1[N:7]([CH3:18])[N:8]=[C:9]([C:11]2[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][CH:12]=2)[CH:10]=1)=O)C.[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[Cl:17][C:14]1[CH:13]=[CH:12][C:11]([C:9]2[CH:10]=[C:6]([CH2:4][OH:3])[N:7]([CH3:18])[N:8]=2)=[CH:16][CH:15]=1

Participants

3

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 45790142Ethyl 3-(4-chlorophenyl)-1-methyl-1H-pyrazole-5-carboxylate

Product 1

HCID 23170490[5-(4-chloro-phenyl)-2-methyl-2H-pyrazol-3-yl]-methanol

Procedure

In analogy to the procedure described for example 1 a], 5-(4-chloro-phenyl)-2-methyl-2H-pyrazole-3-carboxylic acid ethyl ester was reduced with lithium aluminium hydride to give [5-(4-chloro-phenyl)-2-methyl-2H-pyrazol-3-yl]-methanol as colorless crystals.

Sources & evidence

ORD record
ord-f81ace1ab92d4df6985926ae7bc9b43c
Source dataset
uspto-grants-2007_09
Patent number
US07265149B2

Reaction notes

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