Aluminium lithium hydride → [2-(2,2,2-trifluoro-ethyl)-5-(4-trifluoromethyl-phenyl)-2H-pyrazol-3-yl]-methanol

HRID 915439Notes

Reaction equation

HRID 915439 reaction equation
C([O:3][C:4]([C:6]1[N:7]([CH2:21][C:22]([F:25])([F:24])[F:23])[N:8]=[C:9]([C:11]2[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:19])[F:18])=[CH:13][CH:12]=2)[CH:10]=1)=O)C.[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[F:24][C:22]([F:23])([F:25])[CH2:21][N:7]1[C:6]([CH2:4][OH:3])=[CH:10][C:9]([C:11]2[CH:12]=[CH:13][C:14]([C:17]([F:18])([F:19])[F:20])=[CH:15][CH:16]=2)=[N:8]1

Participants

3

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 866006252-(2,2,2-Trifluoro-ethyl)-5-(4-trifluoromethyl-phenyl)-2H-pyrazole-3-carboxylic acid ethyl ester

Product 1

HCID 86600626[2-(2,2,2-trifluoro-ethyl)-5-(4-trifluoromethyl-phenyl)-2H-pyrazol-3-yl]-methanol

Procedure

In analogy to the procedure described for example 1 a], 2-(2,2,2-trifluoro-ethyl)-5-(4-trifluoromethyl-phenyl)-2H-pyrazole-3-carboxylic acid ethyl ester was reduced with lithium aluminium hydride to give [2-(2,2,2-trifluoro-ethyl)-5-(4-trifluoromethyl-phenyl)-2H-pyrazol-3-yl]-methanol as colorless crystals.

Sources & evidence

ORD record
ord-4d7495601f83407abbc58a880ce31070
Source dataset
uspto-grants-2007_09
Patent number
US07265149B2

Reaction notes

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