反应详情

温度

230 °C

A suspension of 6-benzyloxy-4-methyl-1H-indole-2-carboxylic acid (28 mg, 0.95 mmol) and copper chromite (19 mg, 0.06 mmol) in quinoline (1.4 ml) was heated at 230° C. (bath temp.) for 1.5 h. The mixture was poured onto 2 N HCl/ice water 1/1 and extracted three times with ethyl acetate. The combined extracts were washed with saturated aqueous NaHCO3 solution and brine and dried over sodium sulfate. Evaporation of the solvent under reduced pressure left a black oil which was purified by column chromatography (silica gel, n-heptane/AcOEt) to yield 90 mg (0.32 mmol, 34%) of the title compound as brown oil.

1. extractionextracted three times with ethyl acetate
2. washThe combined extracts were washed with saturated aqueous NaHCO3 solution and brine
3. dry with materialdried over sodium sulfate
4. customEvaporation of the solvent under reduced pressure
5. waitleft a black oil which
6. customwas purified by column chromatography (silica gel, n-heptane/AcOEt)