N,N,N',N'-Tetramethylazodicarboxamide → {6-[2-(2,2,2-trifluoro-ethyl)-5-(4-trifluoromethoxy-phenyl)-2H-pyrazol-3-ylmethoxy]-indol-1-yl}-acetic acid ethyl ester

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	N,N,N',N'-Tetramethylazodicarboxamide	HCID 4278	—
Edukt	Tributylphosphine	HCID 13831	—
Edukt	(6-Hydroxy-indol-1-yl)-acetic acid ethyl ester	HCID 68821422	—
Edukt	[2-(2,2,2-trifluoro-ethyl)-5-(4-trifluoromethoxy-phenyl)-2H-pyrazol-3-yl]-methanol	HCID 86600629	—
Produkt	{6-[2-(2,2,2-trifluoro-ethyl)-5-(4-trifluoromethoxy-phenyl)-2H-pyrazol-3-ylmethoxy]-indol-1-yl}-acetic acid ethyl ester	HCID 86600630	—

Reaktionsschritte

In analogy to the procedure described for example 3 c], (6-hydroxy-indol-1-yl)-acetic acid ethyl ester (example 2 e]) was reacted with [2-(2,2,2-trifluoro-ethyl)-5-(4-trifluoromethoxy-phenyl)-2H-pyrazol-3-yl]-methanol in the presence of N,N,N′,N′-tetramethyl azodicarboxamide and tributylphosphine to give {6-[2-(2,2,2-trifluoro-ethyl)-5-(4-trifluoromethoxy-phenyl)-2H-pyrazol-3-ylmethoxy]-indol-1-yl}-acetic acid ethyl ester as yellow oil.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US07265149B2
Quelldatensatz	uspto-grants-2007_09
ORD ID	ord-ed7f2e48ed3a4dd6ad57f185cdbedc89
Quellennotiz	uspto-grants-2007_09