Aluminium lithium hydride → [1-methyl-5-(4-trifluoromethoxy-phenyl)-1H-pyrazol-3-yl]-methanol

HRID 915452Notes

Reaction equation

HRID 915452 reaction equation
C([O:3][C:4]([C:6]1[CH:10]=[C:9]([C:11]2[CH:16]=[CH:15][C:14]([O:17][C:18]([F:21])([F:20])[F:19])=[CH:13][CH:12]=2)[N:8]([CH3:22])[N:7]=1)=O)C.[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[CH3:22][N:8]1[C:9]([C:11]2[CH:12]=[CH:13][C:14]([O:17][C:18]([F:19])([F:20])[F:21])=[CH:15][CH:16]=2)=[CH:10][C:6]([CH2:4][OH:3])=[N:7]1

Participants

3

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 674044291-methyl-5-(4-trifluoromethoxy-phenyl)-1H-pyrazole-3-carboxylic acid ethyl ester

Product 1

HCID 67402876[1-methyl-5-(4-trifluoromethoxy-phenyl)-1H-pyrazol-3-yl]-methanol

Procedure

In analogy to the procedure described for example 1 a], 1-methyl-5-(4-trifluoromethoxy-phenyl)-1H-pyrazole-3-carboxylic acid ethyl ester (example 11 c]) was reduced with lithium aluminium hydride to give [1-methyl-5-(4-trifluoromethoxy-phenyl)-1H-pyrazol-3-yl]-methanol as brown solid.

Sources & evidence

ORD record
ord-c781dd0fce744eb3b941169b07756675
Source dataset
uspto-grants-2007_09
Patent number
US07265149B2

Reaction notes

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