HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylhydrazine → 5-(4-fluoro-3-trifluoromethyl-phenyl)-2-methyl-2H-pyrazole-3-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylhydrazine | HCID 6061 | — |
| Reactant | HCID 178473087 | HCID 178473087 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 5-(4-fluoro-3-trifluoromethyl-phenyl)-2-methyl-2H-pyrazole-3-carboxylic acid ethyl ester | HCID 69282422 | — |
| Product | 5-(4-fluoro-3-trifluoromethyl-phenyl)-1-methyl-1H-pyrazole-3-carboxylic acid ethyl ester | HCID 69282704 | — |
Reaction Steps
In analogy to the procedure described for example 4 b], (Z)-4-(4-fluoro-3-trifluoromethyl-phenyl)-2-hydroxy-4-oxo-but-2-enoic acid ethyl ester was reacted with methylhydrazine in ethanol under reflux conditions to give 5-(4-fluoro-3-trifluoromethyl-phenyl)-2-methyl-2H-pyrazole-3-carboxylic acid ethyl ester as colorless crystals and 5-(4-fluoro-3-trifluoromethyl-phenyl)-1-methyl-1H-pyrazole-3-carboxylic acid ethyl ester as colorless crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07265149B2 |
| Source dataset | uspto-grants-2007_09 |
| ORD ID | ord-7bb5b703fb2d4887ac24a6cd9bc70e00 |
| Source note | uspto-grants-2007_09 |