Aluminium lithium hydride → [5-(4-fluoro-3-trifluoromethyl-phenyl)-2-methyl-2H-pyrazol-3-yl]-methanol

HRID 915461Notes

Reaction equation

C([O:3][C:4]([C:6]1[N:7]([CH3:22])[N:8]=[C:9]([C:11]2[CH:16]=[CH:15][C:14]([F:17])=[C:13]([C:18]([F:21])([F:20])[F:19])[CH:12]=2)[CH:10]=1)=O)C.[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[F:17][C:14]1[CH:15]=[CH:16][C:11]([C:9]2[CH:10]=[C:6]([CH2:4][OH:3])[N:7]([CH3:22])[N:8]=2)=[CH:12][C:13]=1[C:18]([F:20])([F:19])[F:21]

Participants

Reactant 2

HCID 21226445Aluminium lithium hydride

HCID 69282422HCID 69282422, compound

Product 1

HCID 69280241[5-(4-fluoro-3-trifluoromethyl-phenyl)-2-methyl-2H-pyrazol-3-yl]-methanol

Procedure

In analogy to the procedure described for example 1 a], 5-(4-fluoro-3-trifluoromethyl-phenyl)-2-methyl-2H-pyrazole-3-carboxylic acid ethyl ester was reduced with lithium aluminium hydride to give [5-(4-fluoro-3-trifluoromethyl-phenyl)-2-methyl-2H-pyrazol-3-yl]-methanol as white solid.

Sources & evidence

ORD record: ord-8a544783573a4e45a43de7fdc6e14aa7
Source dataset: uspto-grants-2007_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07265149B2

Reaction notes

Loading…