Sodium Hydroxide → [2-methyl-5-(4-trifluoromethoxy-phenyl)-2H-pyrazol-3-yl]-acetic acid

HRID 915466Notes

Reaction equation

HRID 915466 reaction equation
[CH3:1][N:2]1[C:6]([CH2:7][C:8]#N)=[CH:5][C:4]([C:10]2[CH:15]=[CH:14][C:13]([O:16][C:17]([F:20])([F:19])[F:18])=[CH:12][CH:11]=2)=[N:3]1.[OH-:21].[Na+].[OH2:23].C(O)C>>[CH3:1][N:2]1[C:6]([CH2:7][C:8]([OH:23])=[O:21])=[CH:5][C:4]([C:10]2[CH:15]=[CH:14][C:13]([O:16][C:17]([F:20])([F:19])[F:18])=[CH:12][CH:11]=2)=[N:3]1

Participants

4

Reactant 3

HCID 14798Sodium HydroxideHCID 19096565Water ethanolHCID 67402912[2-methyl-5-(4-trifluoromethoxy-phenyl)-2H-pyrazol-3-yl]-acetonitrile

Product 1

HCID 67404748[2-methyl-5-(4-trifluoromethoxy-phenyl)-2H-pyrazol-3-yl]-acetic acid

Procedure

In analogy to the procedure described for example 9 c], [2-methyl-5-(4-trifluoromethoxy-phenyl)-2H-pyrazol-3-yl]-acetonitrile was treated with sodium hydroxide in water/ethanol 1/1 at 85° C. to give [2-methyl-5-(4-trifluoromethoxy-phenyl)-2H-pyrazol-3-yl]-acetic acid as off-white solid.

Sources & evidence

ORD record
ord-d5d52866e1204649bb148d51b3bb66ab
Source dataset
uspto-grants-2007_09
Patent number
US07265149B2

Reaction notes

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