Aluminium lithium hydride → 3-[2-methyl-5-(4-trifluoromethoxy-phenyl)-2H-pyrazol-3-yl]-propan-1-ol

HRID 915472Notes

Reaction equation

HRID 915472 reaction equation
C([O:3][C:4](=O)[CH2:5][CH2:6][C:7]1[N:8]([CH3:23])[N:9]=[C:10]([C:12]2[CH:17]=[CH:16][C:15]([O:18][C:19]([F:22])([F:21])[F:20])=[CH:14][CH:13]=2)[CH:11]=1)C.[H-].[Al+3].[Li+].[H-].[H-].[H-]>C(OCC)C>[CH3:23][N:8]1[C:7]([CH2:6][CH2:5][CH2:4][OH:3])=[CH:11][C:10]([C:12]2[CH:17]=[CH:16][C:15]([O:18][C:19]([F:20])([F:21])[F:22])=[CH:14][CH:13]=2)=[N:9]1

Participants

4

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 674020503-[2-methyl-5-(4-trifluoromethoxy-phenyl)-2H-pyrazol-3-yl]-propionic acid ethyl ester

Product 1

HCID 674025763-[2-methyl-5-(4-trifluoromethoxy-phenyl)-2H-pyrazol-3-yl]-propan-1-ol

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

In analogy to the procedure described for example 1 a], 3-[2-methyl-5-(4-trifluoromethoxy-phenyl)-2H-pyrazol-3-yl]-propionic acid ethyl ester was reduced with lithium aluminium hydride in diethyl ether to give 3-[2-methyl-5-(4-trifluoromethoxy-phenyl)-2H-pyrazol-3-yl]-propan-1-ol as yellow oil.

Sources & evidence

ORD record
ord-8b752560bc6c4ae9bb5857e288606165
Source dataset
uspto-grants-2007_09
Patent number
US07265149B2

Reaction notes

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