Thionyl Chloride → 5-chloromethyl-1-(2,2,2-trifluoro-ethyl)-3-(4-trifluoromethoxy-phenyl)-1H-pyrazole

HRID 915474Notes

Reaction equation

HRID 915474 reaction equation
[F:1][C:2]([F:23])([F:22])[CH2:3][N:4]1[C:8]([CH2:9]O)=[CH:7][C:6]([C:11]2[CH:16]=[CH:15][C:14]([O:17][C:18]([F:21])([F:20])[F:19])=[CH:13][CH:12]=2)=[N:5]1.S(Cl)([Cl:26])=O>C(Cl)(Cl)Cl>[Cl:26][CH2:9][C:8]1[N:4]([CH2:3][C:2]([F:23])([F:22])[F:1])[N:5]=[C:6]([C:11]2[CH:16]=[CH:15][C:14]([O:17][C:18]([F:21])([F:20])[F:19])=[CH:13][CH:12]=2)[CH:7]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 86600629[2-(2,2,2-trifluoro-ethyl)-5-(4-trifluoromethoxy-phenyl)-2H-pyrazol-3-yl]-methanol

Product 1

HCID 866006325-chloromethyl-1-(2,2,2-trifluoro-ethyl)-3-(4-trifluoromethoxy-phenyl)-1H-pyrazole

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

In analogy to the procedure described for example 1 b], [2-(2,2,2-trifluoro-ethyl)-5-(4-trifluoromethoxy-phenyl)-2H-pyrazol-3-yl]-methanol (example 15 b]) was reacted with thionyl chloride in chloroform to yield 5-chloromethyl-1-(2,2,2-trifluoro-ethyl)-3-(4-trifluoromethoxy-phenyl)-1H-pyrazole as colorless oil.

Sources & evidence

ORD record
ord-f323e755176f448a9fc7f82c3ec3bb96
Source dataset
uspto-grants-2007_09
Patent number
US07265149B2

Reaction notes

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