Sodium Hydroxide → HCID 86600634, compound

HRID 915476Notes

Reaction equation

HRID 915476 reaction equation
[F:1][C:2]([F:24])([F:23])[CH2:3][N:4]1[C:8]([CH2:9][C:10]#N)=[CH:7][C:6]([C:12]2[CH:17]=[CH:16][C:15]([O:18][C:19]([F:22])([F:21])[F:20])=[CH:14][CH:13]=2)=[N:5]1.[OH-:25].[Na+].[OH2:27].C(O)C>>[F:1][C:2]([F:24])([F:23])[CH2:3][N:4]1[C:8]([CH2:9][C:10]([OH:27])=[O:25])=[CH:7][C:6]([C:12]2[CH:17]=[CH:16][C:15]([O:18][C:19]([F:22])([F:21])[F:20])=[CH:14][CH:13]=2)=[N:5]1

Participants

4

Reactant 3

HCID 14798Sodium HydroxideHCID 19096565Water ethanolHCID 86600633[2-(2,2,2-trifluoro-ethyl)-5-(4-trifluoromethoxy-phenyl)-2H-pyrazol-3-yl]-acetonitrile

Product 1

HCID 86600634HCID 86600634, compound

Procedure

In analogy to the procedure described for example 9 c], [2-(2,2,2-trifluoro-ethyl)-5-(4-trifluoromethoxy-phenyl)-2H-pyrazol-3-yl]-acetonitrile was treated with sodium hydroxide in water/ethanol 1/1 at 85° C. to give [2-(2,2,2-trifluoro-ethyl)-5-(4-trifluoromethoxy-phenyl)-2H-pyrazol-3-yl]-acetic acid as brown crystals.

Sources & evidence

ORD record
ord-54cb17bdd34a4685861f6cb48f47d20d
Source dataset
uspto-grants-2007_09
Patent number
US07265149B2

Reaction notes

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