Aluminium lithium hydride → [2-difluoromethyl-5-(4-trifluoromethoxy-phenyl)-2H-pyrazol-3-yl]-methanol

HRID 915483Notes

Reaction equation

HRID 915483 reaction equation
C([O:3][C:4]([C:6]1[N:7]([CH:22]([F:24])[F:23])[N:8]=[C:9]([C:11]2[CH:16]=[CH:15][C:14]([O:17][C:18]([F:21])([F:20])[F:19])=[CH:13][CH:12]=2)[CH:10]=1)=O)C.[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[F:24][CH:22]([F:23])[N:7]1[C:6]([CH2:4][OH:3])=[CH:10][C:9]([C:11]2[CH:12]=[CH:13][C:14]([O:17][C:18]([F:20])([F:19])[F:21])=[CH:15][CH:16]=2)=[N:8]1

Participants

3

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 674025302-difluoromethyl-5-(4-trifluoromethoxy-phenyl)-2H-pyrazole-3-carboxylic acid ethyl ester

Product 1

HCID 67402865[2-difluoromethyl-5-(4-trifluoromethoxy-phenyl)-2H-pyrazol-3-yl]-methanol

Procedure

In analogy to the procedure described for example 1 a], 2-difluoromethyl-5-(4-trifluoromethoxy-phenyl)-2H-pyrazole-3-carboxylic acid ethyl ester was reduced with lithium aluminium hydride to give [2-difluoromethyl-5-(4-trifluoromethoxy-phenyl)-2H-pyrazol-3-yl]-methanol as white solid.

Sources & evidence

ORD record
ord-513444bd4625483eb6dc18d206c7ad1f
Source dataset
uspto-grants-2007_09
Patent number
US07265149B2

Reaction notes

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