HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl Acetate → 3-[2-methyl-5-(4-trifluoromethyl-phenyl)-2H-pyrazol-3-yl]-propionic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Lithium diisopropylamide | HCID 2724682 | — |
| Reactant | 5-iodomethyl-1-methyl-3-(4-trifluoromethyl-phenyl)-1H-pyrazole | HCID 69282812 | — |
| Solvent | 2(1H)-Pyrimidinone, tetrahydro-1,3-dimethyl- | HCID 81646 | — |
| Product | 3-[2-methyl-5-(4-trifluoromethyl-phenyl)-2H-pyrazol-3-yl]-propionic acid ethyl ester | HCID 69282485 | — |
Reaction Steps
In analogy to the procedure described in example 20 b], 5-iodomethyl-1-methyl-3-(4-trifluoromethyl-phenyl)-1H-pyrazole was reacted with ethyl acetate in the presence of lithium diisopropylamide and DMPU to obtain 3-[2-methyl-5-(4-trifluoromethyl-phenyl)-2H-pyrazol-3-yl]-propionic acid ethyl ester as yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07265149B2 |
| Source dataset | uspto-grants-2007_09 |
| ORD ID | ord-5ecf6487ed1d4debb57867afacb91247 |
| Source note | uspto-grants-2007_09 |