Acetic Anhydride → HCID 9998367, compound

Participants

Reaction Steps

Diisopropylethylamine (83.2 μL, 477 μmol), followed by acetic anhydride (239 μmol) were added to a solution of 6-amino-2-(4-fluoro-phenyl)-5-methoxy-benzofuran-3-carboxylic acid methylamide, prepared according to Example 17 (75 mg, 239 μmol) in dry trichloromethane (3 mL). After one hour, the reaction was quenched with water (3 mL). After concentration to dryness, the crude oil was purified by HPLC (reverse phase, C18, acetonitrile/water with 0.1% acetic acid) to provide 73 mg (87%) of the title compound.

Provenance & Evidence