HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chlorobenzoic Acid → HCID 69421311, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chlorobenzoic Acid | HCID 8374 | — |
| Reactant | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | HCID 69418756 | HCID 69418756 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 69421311 | HCID 69421311 | 28.7% |
Reaction Steps
4-(3,4-Dichlorophenoxy)-1-piperidineethanesulfonamide (0.1 g), EDCI (0.108 g), HOBT (40 mg), DMAP (40 mg) and 2-chlorobenzoic acid (88 mg) were dissolved in dichloromethane (5 mL) and triethyalamine (0.5 mL) was added. The reaction mixture was stirred for 17 h. The solvents were evaporated. The residue was purified by HPLC (gradient Ammonium acetate/Acetonitrile 95% to 25%; Xterra column) to give the subtitle compound (40 mg)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07265227B2 |
| Source dataset | uspto-grants-2007_09 |
| ORD ID | ord-da32845f59e549dd969b2effa2f9680b |
| Source note | uspto-grants-2007_09 |