HCID 58958600, compound → HCID 58958580, compound

Participants

Reaction Steps

To a mixture of wet palladium on carbon (10 wt %, 10 mg) in EtOH (5 mL) was added 3-(4-fluorophenyl)-1-(2-methylphenyl)-4-vinyl-1H-pyrazol-5-amine (87 mg, 0.30 mmol) in EtOH (5 mL). The reaction was mixed on a Parr shaker under H2 atmosphere (55 psi) for 16 h. The palladium catalyst was filtered through Celite® and rinsed with EtOH (3×20 mL). The solution was concentrated under reduced pressure to afford the title compound (68 mg, 77%) containing trace impurities. This material was used in subsequent reactions without further purification: ES-MS m/z 296.2 (MH+); HPLC RT (min) 2.65.

Provenance & Evidence