反应详情

A solution of 5-(2,4-difluorophenyl)-3-iodo-salicylic acid (1.69 g, 4.61 mmol) in ethanol (20 ml) was cooled to 0° C. and a flow of anhydrous hydrochloride gas was bubbled through for 5 min. The solution was heated under reflux for 4 hr and cooled to room temperature, the solvents were evaporated at low pressure. The residue was dissolved in dichloromethane and the product was worked up. The reaction crude was purified by chromatography on silica gel using hexane/ethyl acetate (7:3) as the eluent.

1. customa flow of anhydrous hydrochloride gas was bubbled through for 5 min
2. temperatureThe solution was heated
3. temperatureunder reflux for 4 hr
4. customthe solvents were evaporated at low pressure
5. dissolutionThe residue was dissolved in dichloromethane
6. customThe reaction crude
7. customwas purified by chromatography on silica gel