化工社化工社 化学情報印刷レポート · 研究参考用
Methanol → Methyl 5-(2,4-difluorophenyl)-3-iodo-salicylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 反応物 | 2',4'-Difluoro-4-hydroxy-5-iodo-1,1'-biphenyl-3-carboxylic acid | HCID 4369563 | — |
| 生成物 | Methyl 5-(2,4-difluorophenyl)-3-iodo-salicylate | HCID 11223005 | — |
反応手順
11.5 ml of methanol and 2.9 ml of thionyl chloride (SOCl2) were placed in a flask under an inert atmosphere. It was stirred for 15 min and 1.67 g (4.56 mmol) of 5-(2,4-difluorophenyl)-3-iodo-salicylic acid was added. It was stirred continuously at room temperature until no evolution was observed by HPLC. The solvent was evaporated at low pressure and extraction was carried out with ethyl acetate. A crude of 97% purity was obtained and then purified by chromatography on silica gel.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07265245B2 |
| 出典データセット | uspto-grants-2007_09 |
| ORD ID | ord-59e3d2ae053b4a8eae33e1d99e598390 |
| 出典メモ | uspto-grants-2007_09 |