反应详情

Mix and suspend 3-thiazol-2-yl-acrylic acid (580 mg, 3.74 mmol) and 5% Pd/C (270 mg) in ethanol (200 mL). Purge the mixture with nitrogen. Then purge with hydrogen for 30 minutes and stir under 1 atmosphere of hydrogen for 6 hours. Filter the reaction mixture through Celite® and wash the filter cake with additional ethanol. Concentrate the filtrate to afford 550 mg (94%) of 3-thiazol-2-yl-propionic acid as a white solid. MS: m/e=158 (MH+).

1. additionMix
2. customPurge the mixture with nitrogen
3. customThen purge with hydrogen for 30 minutes
4. filtrationFilter the reaction mixture through Celite®
5. washwash the filter cake with additional ethanol
6. concentrationConcentrate the filtrate