反应详情

Heat a solution of N-(2-oxopropyl)benzamide (1.0 g, 5.65 mmol) in concentrated H2SO4 (10 mL) at 100° C. for 1 hour. Cool the reaction, pour over ice, neutralize with solid Na2CO3, and extract with ethyl acetate (200 mL). Wash the organic phase with brine (75 mL), dry (Na2SO4), filter, and concentrate to afford a yellow oil. Perform flash chromatography on silica gel, eluting with 100% ethyl acetate, to afford 790 mg (88% yield) of 5-methyl-2-phenyloxazole. MS: m/e=160 (MH+)

1. temperatureCool
2. customthe reaction
3. additionpour over ice
4. extractionextract with ethyl acetate (200 mL)
5. washWash the organic phase with brine (75 mL)
6. dry with materialdry (Na2SO4)
7. filtrationfilter
8. concentrationconcentrate
9. customto afford a yellow oil
10. washPerform flash chromatography on silica gel, eluting with 100% ethyl acetate