HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 915670Generated: October 25, 2026
2-Propynoic acid, 3-phenyl-, ethyl ester → Ethyl-4-phenyl-3-furoate
https://huagongshe.com/reaction/915670
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Propynoic acid, 3-phenyl-, ethyl ester | HCID 91516 | — |
| Reactant | 4-Phenyl-1,3-oxazole | HCID 589279 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | Ethyl-4-phenyl-3-furoate | HCID 15037153 | 78.4% |
Reaction Steps
Mix 4-Phenyl oxazole (3.33 g, 23.0 mmol) and ethyl phenylpropiolate (4.0 g, 23.0 mmol) in a sealed tube and heat at 220° C. for 20 hours. Perform flash-chromatography on silica gel eluting with 4:1 Hex/ethyl acetate to afford 3.9 g of 4-phenylfuran-3-carboxylic acid ethyl ester as a yellow oil. MS: m/e=217 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07265246B2 |
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| Source dataset | uspto-grants-2007_09 |
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| ORD ID | ord-9fd118029536481387b3a1242356d996 |
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| Source note | uspto-grants-2007_09 |
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