Hydrochloric Acid → HCID 86604718, compound

Participants

Reaction Steps

10 mg (0.258 mmol) of NaBH4 are added to a suspension of the compound obtained in Step B (75 mg, 0.198 mmol) in 1 ml of ethanol. The suspension is stirred for 30 minutes at ambient temperature and is then cooled in an ice bath. The reaction mixture is neutralised by adding 1N HCl and extracted with ethyl acetate. The organic phase is washed with saturated NaCl solution, dried (MgSO4) and evaporated in vacuo. The evaporation residue is crystallised from CH2Cl2. The expected compound is recovered by filtration.

Provenance & Evidence