反应详情

温度

100 °C

150 mg of the compound obtained in Step A of Example 1 are dissolved in 8 ml of acetonitrile, to which 300 mg of K2CO3 and 0.15 ml of 1-bromo-4-fluorobutane are added. The reaction mixture is introduced into a sealed autoclave and is heated at 100° C. for 3 hours. After cooling, the solvent is evaporated off under reduced pressure and the residue is taken up in a minimum of water. The insoluble material is collected by filtration, washed with water and dried. The precipitate is then recrystallised from a minimum of ethyl acetate with the aid of heat. After cooling, the title compound is collected by filtration, washed with a minimum of ethyl acetate and dried.

1. additionare added
2. additionThe reaction mixture is introduced into a sealed autoclave
3. temperatureAfter cooling
4. customthe solvent is evaporated off under reduced pressure
5. filtrationThe insoluble material is collected by filtration
6. washwashed with water
7. customdried
8. customThe precipitate is then recrystallised from a minimum of ethyl acetate with the aid
9. temperatureof heat
10. temperatureAfter cooling
11. filtrationthe title compound is collected by filtration
12. washwashed with a minimum of ethyl acetate
13. customdried