Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 915780Generated: October 31, 2026

HCID 67110179, compound → HCID 67110253, compound

https://huagongshe.com/reaction/915780

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHCID 67110179HCID 67110179—
Solvent1,1-DichloroethaneHCID 6365—
SolventTrifluoroacetic acidHCID 6422—
ProductHCID 67110253HCID 6711025358%

Reaction Steps

Step 14B [9058-121-2]: 3-Methyl-2-[4′-(quinolin-2-yloxy)-biphenyl-4-sulfonylamino]-butyric acid tert-butyl ester (164 mg) was dissolved in dichloroethane (12 mL) and hydrolyzed with TFA (4 mL) at room temperature over a period of 4 hrs. Solvent was removed and crude was purified by column chromatography (Eluent 10% MeOH/DCE) to afford 3-Methyl-2-[4′-(quinolin-2-yloxy)-biphenyl-4-sulfonylamino]-butyric acid in 58% yield (84.8 mg).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07268135B2
Source datasetuspto-grants-2007_09
ORD IDord-07ec1f37a6f942499a9bf1a878363109
Source noteuspto-grants-2007_09