Sulfuric Acid → 5-Bromoisoquinoline-8-sulfonic acid

Participants

Reaction Steps

To fuming sulfuric acid at 0° C. was added 5-bromoisoquinoline (20.0 g, 96 mmol), The resultant mixture was warmed to 200° C. for 4 h and was then cooled to rt and poured into 500 mL of ice water. The product was removed via filtration, washed with water and acetone, and dried to give 25 g (90%) of a white solid.

Provenance & Evidence