Sodium Hydroxide → HCID 178517606, compound

Participants

Reaction Conditions

Reaction Steps

A stirred mixture of 7-chloro-3-(4-chlorophenyl)-2-(2-chlorophenyl)-2H-pyrazolo[3,4-c]pyridine (I-1A-6a; 420 mg, 1.12 mmol) in 3M aqueous HCl (7.5 ml) and tetrahydrofuran (12 ml) was heated overnight at 45° C. The reaction mixture was cooled and the pH adjusted to 8 with 5M aqueous NaOH. The aqueous layer was dried (Na2SO4), concentrated, in vacuo, and the resulting solid repulped from 40% ethyl acetate/isopropyl ether (20 ml) to afford I-10A-14a as an off-white solid (320 mg, 80%): +ESI MS (M+1) 356.3; 1H NMR (400 MHz, CD2Cl2) δ 9.64 (br s, 1H), 7.55-7.41 (m, 4H), 7.34 (d, J=8.7 Hz, 2H), 7.21 (d, J=8.7 Hz, 2H), 6.96 (dd, J=7.5, 5.8 Hz, 1H), 6.50 (d, J=7.5 Hz, 1H).

Provenance & Evidence