Sodium Hydroxide → HCID 136000719, compound

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Reaction Steps

To a 2 ml methanol/3 ml tetrahydrofuran mixed solution of 82 mg (0.15 mmol) of the compound obtained in Example 53, 1 ml (1 mmol) of a 1M aqueous solution of sodium hydroxide was added, and the mixture was stirred at room temperature for 1 hour. Then, the solvent was distilled off under reduced pressure, and the residue was diluted with water. The aqueous layer was washed with ether, then acidified with a 2M aqueous solution of hydrochloric acid, and extracted with dichloromethane. The organic layer was washed with water and a saturated aqueous solution of sodium chloride. After the washed layer was dried over anhydrous sodium sulfate, the solvent was distilled off under reduced pressure to obtain 77 mg (99%) of the captioned compound.

Provenance & Evidence