Fumaric Acid → HCID 136355234, compound

HRID 915943Notes

Reaction equation

[CH:1]1([N:7]2[C:15]3[C:14](=[O:16])[NH:13][C:12]([C:17]4[CH:22]=[CH:21][C:20]([N:23]([CH3:28])[CH2:24][CH2:25][NH:26][CH3:27])=[CH:19][C:18]=4[O:29][CH3:30])=[N:11][C:10]=3[C:9]([CH3:31])=[N:8]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[C:32]([OH:39])(=[O:38])/[CH:33]=[CH:34]/[C:35]([OH:37])=[O:36]>>[C:32]([OH:39])(=[O:38])/[CH:33]=[CH:34]/[C:35]([OH:37])=[O:36].[CH:1]1([N:7]2[C:15]3[C:14](=[O:16])[NH:13][C:12]([C:17]4[CH:22]=[CH:21][C:20]([N:23]([CH3:28])[CH2:24][CH2:25][NH:26][CH3:27])=[CH:19][C:18]=4[O:29][CH3:30])=[N:11][C:10]=3[C:9]([CH3:31])=[N:8]2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

Reactant 2

HCID 444972Fumaric Acid

HCID 136005847HCID 136005847, compound

Product 1

HCID 136355234HCID 136355234, compoundYield 75%

Procedure

The same reaction procedure as in Example 62 was performed, except that the compound obtained in Example 102 was used in place of the compound obtained in Example 61, and fumaric acid was used in place of methanesulfonic acid. In this manner, 96 mg (75%) of the captioned compound was obtained.

Workup

customThe same reaction procedure as in Example 62

Sources & evidence

ORD record: ord-4c94e13eb7be4759a256059e2e1b6931
Source dataset: uspto-grants-2007_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07268128B2

Reaction notes

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