Fumaric Acid → HCID 136342087, compound

HRID 915944Notes

Reaction equation

[CH:1]1([N:7]2[C:15]3[C:14](=[O:16])[NH:13][C:12]([C:17]4[CH:22]=[CH:21][C:20]([N:23]([CH3:29])[CH2:24][CH2:25][CH2:26][NH:27][CH3:28])=[CH:19][C:18]=4[O:30][CH3:31])=[N:11][C:10]=3[C:9]([CH3:32])=[N:8]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[C:33]([OH:40])(=[O:39])/[CH:34]=[CH:35]/[C:36]([OH:38])=[O:37]>>[C:33]([OH:40])(=[O:39])/[CH:34]=[CH:35]/[C:36]([OH:38])=[O:37].[CH:1]1([N:7]2[C:15]3[C:14](=[O:16])[NH:13][C:12]([C:17]4[CH:22]=[CH:21][C:20]([N:23]([CH3:29])[CH2:24][CH2:25][CH2:26][NH:27][CH3:28])=[CH:19][C:18]=4[O:30][CH3:31])=[N:11][C:10]=3[C:9]([CH3:32])=[N:8]2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

Reactant 2

HCID 444972Fumaric Acid

HCID 136005770HCID 136005770, compound

Product 1

HCID 136342087HCID 136342087, compoundYield 84%

Procedure

The same reaction procedure as in Example 62 was performed, except that the compound obtained in Example 110 was used in place of the compound obtained in Example 61, and fumaric acid was used in place of methanesulfonic acid. In this manner, 92 mg (84%) of the captioned compound was obtained.

Workup

customThe same reaction procedure as in Example 62

Sources & evidence

ORD record: ord-b4b848206b4d4a17a5bc2685d36b9c1a
Source dataset: uspto-grants-2007_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07268128B2

Reaction notes

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