1,4-Dioxane hydrochloride → HCID 136333438, compound

HRID 915945Notes

Reaction equation

HRID 915945 reaction equation
[CH:1]1([N:7]2[C:15]3[C:14](=[O:16])[NH:13][C:12]([C:17]4[CH:22]=[CH:21][C:20]([N:23]([CH2:26][CH2:27][OH:28])[CH2:24][CH3:25])=[CH:19][C:18]=4[O:29][CH3:30])=[N:11][C:10]=3[C:9]([CH3:31])=[N:8]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[ClH:32].O1CCOCC1>>[ClH:32].[CH:1]1([N:7]2[C:15]3[C:14](=[O:16])[NH:13][C:12]([C:17]4[CH:22]=[CH:21][C:20]([N:23]([CH2:26][CH2:27][OH:28])[CH2:24][CH3:25])=[CH:19][C:18]=4[O:29][CH3:30])=[N:11][C:10]=3[C:9]([CH3:31])=[N:8]2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

3

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 136005906HCID 136005906, compound

Product 1

HCID 136333438HCID 136333438, compoundYield 87%

Procedure

The same reaction procedure as in Example 62 was performed, except that the compound obtained in Example 114 was used in place of the compound obtained in Example 61, and a 4N-hydrochloric acid/1,4-dioxane solution was used in place of methanesulfonic acid. In this manner, 104 mg (87%) of the captioned compound was obtained.

Workup

  1. customThe same reaction procedure as in Example 62

Sources & evidence

ORD record
ord-dd9f75d4b42d4cd2b0d1178e2270b462
Source dataset
uspto-grants-2007_09
Patent number
US07268128B2

Reaction notes

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