Hexahydro-1,4-diazepine → HCID 136005917, compound

HRID 915973Notes

Reaction equation

HRID 915973 reaction equation
[CH:1]1([C:7]2[C:15]3[C:14](=[O:16])[NH:13][C:12]([C:17]4[CH:22]=[CH:21][C:20]([S:23](Cl)(=[O:25])=[O:24])=[CH:19][CH:18]=4)=[N:11][C:10]=3[N:9]([CH3:27])[N:8]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[NH:28]1[CH2:34][CH2:33][CH2:32][NH:31][CH2:30][CH2:29]1>>[CH:1]1([C:7]2[C:15]3[C:14](=[O:16])[NH:13][C:12]([C:17]4[CH:22]=[CH:21][C:20]([S:23]([N:28]5[CH2:34][CH2:33][CH2:32][NH:31][CH2:30][CH2:29]5)(=[O:25])=[O:24])=[CH:19][CH:18]=4)=[N:11][C:10]=3[N:9]([CH3:27])[N:8]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 68163Hexahydro-1,4-diazepineHCID 136005924HCID 136005924, compound

Product 1

HCID 136005917HCID 136005917, compoundYield 37%

Procedure

The same reaction procedure as in Example 49 was performed, except that the compound obtained in Example 181 was used in place of the compound obtained in Example 48, and homopiperazine was used in place of N-methylpiperazine. In this manner, 64 mg (37%) of the captioned compound was obtained.

Workup

  1. customThe same reaction procedure as in Example 49

Sources & evidence

ORD record
ord-a3901007fe9244df966894529c418fc9
Source dataset
uspto-grants-2007_09
Patent number
US07268128B2

Reaction notes

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