Hexahydro-1,4-diazepine → HCID 136005785, compound

HRID 915976Notes

Reaction equation

HRID 915976 reaction equation
[CH:1]1([C:7]2[C:15]3[C:14](=[O:16])[NH:13][C:12]([C:17]4[CH:22]=[CH:21][C:20]([S:23](Cl)(=[O:25])=[O:24])=[CH:19][C:18]=4[O:27][CH3:28])=[N:11][C:10]=3[N:9]([CH2:29][CH3:30])[N:8]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[NH:31]1[CH2:37][CH2:36][CH2:35][NH:34][CH2:33][CH2:32]1>>[CH:1]1([C:7]2[C:15]3[C:14](=[O:16])[NH:13][C:12]([C:17]4[CH:22]=[CH:21][C:20]([S:23]([N:31]5[CH2:37][CH2:36][CH2:35][NH:34][CH2:33][CH2:32]5)(=[O:25])=[O:24])=[CH:19][C:18]=4[O:27][CH3:28])=[N:11][C:10]=3[N:9]([CH2:29][CH3:30])[N:8]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 68163Hexahydro-1,4-diazepineHCID 136005914HCID 136005914, compound

Product 1

HCID 136005785HCID 136005785, compoundYield 59%

Procedure

The same reaction procedure as in Example 49 was performed, except that the compound obtained in Example 206 was used in place of the compound obtained in Example 48, and homopiperazine was used in place of N-methylpiperazine. In this manner, 100 mg (59%) of the captioned compound was obtained.

Workup

  1. customThe same reaction procedure as in Example 49

Sources & evidence

ORD record
ord-9430bb97d44d44c9bb5b5a5d0822d2cc
Source dataset
uspto-grants-2007_09
Patent number
US07268128B2

Reaction notes

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